Endoplasmic reticulum stress causes EBV lytic replication

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LYMPHOID NEOPLASIA Endoplasmic reticulum stress causes EBV lytic replication

Endoplasmic reticulum (ER) stress triggers a homeostatic cellular response in mammalian cells to ensure efficient folding, sorting, and processing of client proteins. In lytic-permissive lymphoblastoid cell lines (LCLs), pulse exposure to the chemical ER-stress inducer thapsigargin (TG) followed by recovery resulted in the activation of the EBV immediate-early (BRLF1, BZLF1), early (BMRF1), and...

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ژورنال

عنوان ژورنال: Blood

سال: 2011

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood-2011-04-347112